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Nasal sprays are designed to deliver a precise drug dose to the correct absorption site within the nasal mucosa. The spray pump produces the droplet-size distribution, which must be optimized to increase nasal deposition and minimize lung deposition or absorption via the gastrointestinal tract. In this study, two nasal spray pumps were used to evaluate the effectiveness of manual and automated actuation and the effects of variations in actuation parameters on the resultant droplet-size distributions.

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